Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)-
MAC-545496
CAS: 838810-96-1
Molecular Formula: C18H18ClN5O3S
Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- - Names and Identifiers
Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- - Physico-chemical Properties
| Molecular Formula | C18H18ClN5O3S |
| Molar Mass | 419.89 |
| Density | 1.458±0.06 g/cm3(Predicted) |
| Solubility | Soluble in DMSO (25 mg/ml) |
| Appearance | solid |
| Color | Yellow/orange |
| pKa | 7.09±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month |
Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.382 ml | 11.908 ml | 23.816 ml |
| 5 mM | 0.476 ml | 2.382 ml | 4.763 ml |
| 10 mM | 0.238 ml | 1.191 ml | 2.382 ml |
| 5 mM | 0.048 ml | 0.238 ml | 0.476 ml |
Last Update：2024-01-02 23:10:35
Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)- - Reference Information
| biological activity | MAC-545496 is a glycopeptide-resistance-associated protein R(GraR) inhibitor at nanomolar concentrations, it has strong binding affinity for the full-length GraR protein (Kd <0.1 nM). MAC-545496 reverses β-lactam resistance in Methicillin-resistant strains and acts synergistically with CAMP. MAC-545496 showed significant activity in macrophages and attenuated S. Aureus virulence in the alfalfa Rhizobium larval infection model. |
| Target | Value |
| GraR (Cell-free assay) | 0.1 nM(Kd) |
Last Update：2024-04-10 22:29:15
![Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)-](http://res.chembk.com/assets/str/2d/8/83/838810-96-1.png)
Supplier List
Spot supply
Product Name: MAC-545496 Visit Supplier Webpage Request for quotationCAS: 838810-96-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: MAC-545496 Visit Supplier Webpage Request for quotationCAS: 838810-96-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History